Van de Ven Double Ends Everton's Run at New Home Ground
The Dutch defender became the first defender to score twice in a English top-flight match for Tottenham since Jan Vertonghen in March 2013.
At a glance
Micky Van de Ven nods home twice in first half
The home side's defender has goal ruled after video check
Senegalese midfielder nets final goal in 89th minute
This loss is Everton's initial at their new ground
The Tottenham defender scored on two occasions as Spurs prolonged their winning streak on the road in the top division and handed the Toffees their first defeat at their new home.
The Toffees were unbeaten in their five previous fixtures at their recently opened stadium at Bramley-Moore Dock, having departed their historic home behind after more than a century at the end of last season.
But Tottenham's leader Van de Ven struck twice from set-pieces in the opening 45 minutes to place their strong form at risk, and they were unable to turn it around before the midfielder - assisted by former Toffees attacker Richarlison - headed home a final goal to seal the victory.
The Everton defender believed he had equalized the tally a short while after the defender's opener, glancing a powerful header past the Spurs keeper from an set-piece.
The Portuguese striker, meanwhile, missed a number of opportunities, while the Italian goalkeeper made a series of excellent stops to ensure Tottenham went five matches on the road unbeaten in the Premier League.
But the video assistant referee intervened, instructing the match official to review the score on the pitchside monitor and the referee decided that the winger and the attacker were in an illegal position and had interfered with the Tottenham goalkeeper.
The win moves the manager's side into third place in the Premier League, a handful of points off north London rivals and leaders the Gunners.
Everton stay 14th and sit six points ahead of the drop zone.
Spurs breakdown: The defender fulfils duties at each end of the field
After a drab midweek display in the European competition against Monaco, where they mustered a only attempts on goal, the manager opted for Randal Kolo Muani in attack instead of ex-Everton forward Richarlison.
The new arrival was unable to make much of an impact before being substituted for Richarlison after 60 minutes on the field, but it turns out he proved unnecessary in the final outcome.
Defender the Dutchman converted into an attacking force to be feared.
Tottenham's opening strike came from a cleverly executed corner routine, with the midfielder directing the ball toward the face of goal for an unmarked the defender to head home.
And Ven de Ven - stepping up as captain in Cristian Romero's absence - added his second in added time as he rose above Jordan Pickford to head home.
Van de Ven was equally outstanding in defence, partnering well with Kevin Danso as the pair handled superbly with the 34 crosses sent their way by Everton.
Toffees breakdown: Toffees missing striker's instinct
Everton's new home had been a happy hunting ground, but it appears the novelty may have faded somewhat and supporters flocked to the exits after the midfielder's final goal for Spurs.
The end in Everton's unbeaten home run won't be a massive concern for the manager, but their attacking woes will be.
The forward and Thierno Barry - the Toffees' pair of established strikers - had netted only a single goal between them before Sunday's match.
And they were unable to contribute to that miserable tally on a damp and dreary night on in Liverpool.
The striker's performance was epitomized when he chose to overhead kick a clear chance from close range, even with having room and time to reposition for a simpler attempt that would have challenged the keeper.
The substitute, too, was unable to influence the game after coming on for the starter in the 65th minute.
It was not for a shortage of chance. The majority of Everton's attacks came through the winger and Ndiaye, who tirelessly delivered threatening balls into the Tottenham box.
What next for these two sides?
The Toffees: The team head to the Stadium of Light in the Premier League on early November at 20:00 GMT.
Spurs: Spurs travel to St James' Park on Wednesday, 29 October for their next round Carabao Cup match against the Magpies.